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Editorial |

Measuring Eosinophils to Make Treatment Decisions in Asthma

Parameswaran Nair, MD, PhD; Paul M. O’Byrne, MB, FCCP
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST the following: P. N. is supported by the Frederick E. Hargreave Teva Innovation Chair in Airway Diseases. P. M. O. and P. N. are supported by the AllerGen National Centre of Excellence. Both P. N. and P. M. O. have held grants-in-aid from GSK for the investigation of mepolizumab. P. N. also reports grants from AstraZeneca, Sanofi, Teva, Novartis, Boehringer Ingelheim, and Roche, and honoraria for consultancies and lectures from Sanofi, Roche, Teva, AstraZeneca, Knopp, and Daiichi Sankyo. P. M. O. also reports grants and personal fees from AstraZeneca; personal fees from Chiesi, Boehringer Ingelheim, GSK, MedImmune, Merck, Takeda, and Abbott; and grants from Amgen, Novartis, Genentech, Axican, and Alakos outside of the submitted work.

Division of Respirology, Department of Medicine, McMaster University and St Joseph’s Healthcare, Hamilton, ON, Canada

CORRESPONDENCE TO: Paul M. O’Byrne, MB, FCCP, McMaster University Medical Centre, 1280 Main St W, Hamilton, ON, Canada, L8S 4L8


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(3):485-487. doi:10.1016/j.chest.2016.07.009
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Extract

The recognition of the association between eosinophils and asthma is not new. Following its discovery by Jones in 1846 and Ehrlich’s identification of its proclivity for aniline dyes to stain its granules, the progress in elucidating the biological characteristics of eosinophils has been described in four phases. The first related to the refinement of staining techniques; the second was the description of the association between eosinophils and allergic diseases, including asthma; the third related to the granular chemical and biological features of eosinophils; and the fourth is the current era of the development of strategies to specifically target the molecular pathways that are involved in the development, maturation, and trafficking of eosinophils.

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