A 24-year-old woman was evaluated in our ED for 2 weeks’ duration of subjective fevers, chills, and generalized fatigue. Her history is significant for intravenous (IV) drug abuse. Review of systems did not reveal any other symptoms such as chest pain, shortness of breath, or headaches. On presentation, she had blood pressure of 124/62, heart rate of 97 beats/min, respiratory rate of 18 breaths/min, and oral temperature of 100.2°F. Pulse oximetry was 97% on room air. Physical examination was unremarkable. Electrocardiogram was normal. Chest radiography showed normal cardiac silhouette with normal lung fields. Laboratory workup showed an erythrocyte sedimentation rate of 38 mm/h, a C-reactive protein of 105 mg/L, and total leukocytic count of 14,000/mm3. Blood culture was drawn, and broad-spectrum antibiotics were administered. Given her history of IV drug abuse, we proceeded to a two-dimensional transthoracic echocardiogram (TTE) to rule out infective endocarditis.