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Recent Advances in Chest Medicine |

Pulmonary Hypertension in Diffuse Parenchymal Lung Diseases

Oksana A. Shlobin, MD; A. Whitney Brown, MD; Steven D. Nathan, MD
Author and Funding Information

Conflict of Interest

OAS is a consultant for and is on the speakers’ bureau for Actelion, Bayer Pharmaceutical and United Therapeutics and received research funding from Gilead, Boerhinger-Ingelheim and Bayer Pharmaceutical.

AWB has received research funding from Gilead and Bayer Pharmaceutical.

SDN is a consultant, has received research funding and is on the speakers’ bureau for Gilead Sciences, Bayer Pharmaceutical, Boerhinger-Ingelheim, Genentech and United Therapeutics.

1Advanced Lung Disease and Transplant Program, Inova Heart and Vascular Institute, Inova Fairfax Hospital, 3300 Gallows Rd, Falls Church, VA 22042

Corresponding author: Oksana A, Shlobin


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.08.002
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Abstract

Pulmonary hypertension (PH) can be triggered by any number of disease processes that result in increased pulmonary vascular resistance. Although historically associated with idiopathic pulmonary arterial hypertension (iPAH), the majority of patients with PH do not have the idiopathic subtype, but rather PH associated with another underlying diagnosis, such as left heart or lung disease. The World Health Organization (WHO) classification of PH helps conceptualize the different categories based on presumed etiology. WHO group 3 is PH associated with lung disease. This review focuses on PH in diffuse parenchymal lung diseases (DPLD) such as the idiopathic interstitial pneumonias and other more rare forms of DPLD. Although there are clear associations of PH with DPLD, the exact pathophysiologic mechanisms and full clinical significance remain uncertain. Treatment of PH related to DPLD remains investigational, but an area of great interest given the negative prognostic implications and the growing number of available pulmonary vasoactive agents.


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