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Recent Advances in Chest Medicine |

Surgical Lung Biopsy for Interstitial Lung Diseases

Rishi Raj, MD; Kirtee Raparia, MD; David A. Lynch, MD; Kevin K. Brown, MD
Author and Funding Information

aDepartment of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL

bDepartment of Pathology, Northwestern University, Chicago, IL

cDepartment of Radiology, National Jewish Health, Denver, CO

dDepartment of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO

CORRESPONDENCE TO: Rishi Raj, MD, Northwestern University, Pulmonary and Critical Care Medicine, 676 N St. Clair St, Ste 1400, Chicago, IL 60611.


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2017;151(5):1131-1140. doi:10.1016/j.chest.2016.06.019
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This review addresses common questions regarding the role of surgical lung biopsy (SLB) in the diagnosis and treatment of interstitial lung disease (ILD). We specifically address when a SLB can be diagnostic as well as when it may be avoided; for example, when the combination of the clinical context and the imaging pattern seen on high-resolution CT (HRCT) chest scans can provide a confident diagnosis. Existing studies on the diagnostic utility as well as the complications associated with SLB are reviewed; also reviewed are the performance characteristics and reliability of HRCT scans of the chest in predicting the underlying histopathologic findings of the lung. The review is formatted in the form of answers to questions that clinicians regularly ask when considering an SLB in a patient with ILD.

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