In this issue of Chest, Yarmus et al take cryo-TBB to the next level. As with other modern technologies (laptops, smartphones, etc), they fit big things in smaller packages. In a prospective randomized controlled porcine study evaluating a novel sheath cryobiopsy, the authors address a limitation of standard cryo-TBB: that the cryoprobe, the specimen, and the bronchoscope have to be removed from the airway immediately after each freeze biopsy because the specimen obtained is too big to fit through the working channel. When the scope is removed, airway visualization is temporarily lost and major bleeding can occur unchecked, so a secured airway (ie, endotracheal tube) is frequently used to allow rapid reinsertion of the bronchoscope to visualize and attempt to control any bleeding. The sheath cryobiopsy (S-CBx) in this study overcomes this limitation by using a smaller diameter cryoprobe that fits inside a sheath that can be completely retracted through a working channel while the bronchoscope is left in position within the airway.