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Original Research |

Long-term outcomes of patients with ground-glass opacities detected using computed tomography

Shigeki Sawada, MD, PhD; Natsumi Yamashita, MD, PhD; Ryujiro Sugimoto, MD, PhD; Tsuyoshi Ueno, MD, PhD; Motohiro Yamashita, MD, PhD
Author and Funding Information

None of the authors have any financial or other potential conflicts of interest to declare.

Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan

∗∗Division of Clinical Biostatistics, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan

Address correspondence to: Dr. Shigeki Sawada, Department of Thoracic Surgery, Shikoku Cancer Center, 160 Minamiumemoto-cho Kou, Matsuyama-shi, Ehime, 791-0280, Japan; .


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.07.007
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Abstract

Background  The long-term outcomes of follow-up care for ground-glass opacity (GGO) need to be clarified.

Methods  Between 2000 and 2005, 226 patients with pure or mixed GGOs of 3 cm or smaller in size were registered. The CT findings and changes in the findings during the follow-up period and the outcomes of the 226 patients were subsequently reviewed.

Results  Overall, 124 patients underwent resections, 57 did not receive follow-up examinations after 68 months because of stable disease or disease reduction and 45 were continuing to receive follow-up examinations. Thirty-nine patients showed tumor growth during the follow-up period. Among the patients with a ratio of the diameter of consolidation relative to the tumor diameter (CTR) >0, all the cases with tumor growth were identified within 3 years; meanwhile, more than 3 years were required to identify tumor growth in 16% of the patients with a CTR =0. Aggressive cancer occurred in 4% of the patients with a CTR =0 and in 70% of the patients with a CTR >25%. Aggressive cancer was observed in 46% of the patients whose CTR increased during the follow-up period and in 8% of the patients whose tumors increased in size.

Conclusion  A higher CTR and an increase in the CTR during the follow-up were associated with invasive cancer. A follow-up period of 3 years is considered to be adequate for judging tumor growth in patients with a CTR >0, while a longer follow-up period might be needed for patients with a CTR =0.


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