So what is meant by loss of asthma control? Does it differ from an exacerbation? Is it essentially a pre-exacerbation? Let us examine the known factors that cause exacerbations, since the loss of control, if not already an exacerbation, is considered to be potential, pending, or imminent but not quite yet an exacerbation. Symptoms requiring increased reliever medication, especially with an increase in nocturnal symptoms, is a full-blown exacerbation by my standards even though that is described as still in the yellow zone and not an actual exacerbation. After all, when the child’s sleep is disturbed, no one else in the home is likely to be sleeping well. As a parent, I would certainly consider that an exacerbation, not just loss of control. Why bother with the yellow zone, something intermediate between loss of control and an exacerbation requiring optimally effective intervention? I will answer that rhetorical question. Do not bother with the yellow zone loss of control. It is a procrastinator’s zone based on wishful thinking and gambling. Gambling that the exacerbation will run a benign course, which it undoubtedly sometimes, but unpredictably, does. A randomized controlled clinical trial of starting an oral corticosteroid or placebo early at the beginning of an exacerbation (ie, loss of control) was associated with about one-half of the placebo treated patients having a relatively benign course. There did not appear to be any identifiable clinical characteristics at the time of early symptoms among those placebo treated patients whose exacerbation progressed and needed rescue compared with those who recovered spontaneously, other than coughing more than those who received the oral corticosteroid. Had those placebo-treated patients received an inhaled corticosteroid, benefit would have been attributed to that treatment. The question is whether inhaled corticosteroids would have been as likely to match the benefit seen from the oral corticosteroids in that study.