0
Editorial |

Reduced Cardiovascular Morbidity in Obesity-Hypoventilation Syndrome: An Ischemic Preconditioning Protective Effect?

Lena Lavie, PhD; Peretz Lavie, PhD
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

CORRESPONDENCE TO: Lena Lavie, PhD, The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, POB 9649, 31096, Haifa, Israel


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(1):5-6. doi:10.1016/j.chest.2016.02.659
Text Size: A A A
Published online

Extract

The resemblance between obese sleepy patients and Joe, the sleepy character in Dickens’s book The Pickwickian Papers was first alluded to in the medical literature toward the end of the 19th century. Monitoring respiration in Pickwickian patients during sleep uncovered repeated apneic episodes causing intermittent hypoxia and sleep fragmentation which led to the description of OSA. Since then, it has been established that despite similar presenting symptoms and patterns of sleep-disordered breathing, some Pickwickian patients also have chronic daytime hypoventilation. These patients are designated as having obesity-hypoventilation syndrome (OHS) that is distinctly different than OSA. OHS is defined by the presence of daytime hypercapnia (PAco2 ≥ 45 mm Hg), sleep-disordered breathing, and obesity (BMI ≥ 30 kg/m2), after exclusion of all other possible causes of chronic hypercapnia. However, the diagnostic criteria of OHS, particularly with respect to the necessity of sleep-disordered breathing and hypercapnia, are still controversial.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543