Second, the argument of increasing colloid osmotic pressure carries much more weight in the original Starling equation than in the revised Starling principle and glycocalyx model. In the latter, colloid osmotic pressure has no effect on transendothelial filtration rate in conditions of lower capillary pressures, where transcapillary flow approaches zero. Both crystalloids and colloids are retained in the intravascular space until the transcapillary pressure reaches a hydrostatic threshold. This concept, known as the “no absorption rule,” is proposed to explain the failure of colloids to improve clinical outcomes. If our opponent’s argument held true, then protocols limiting the use of albumin in ICUs should show a potential signal of harm. However, such protocols have been published from surgical ICUs and demonstrated no impact on ICU mortality or length of stay.