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Editorials: Point and Counterpoint |

COUNTERPOINT: Should Intravenous Albumin Be Used for Volume Resuscitation in Severe Sepsis/Septic Shock? No

Angel O. Coz Yataco, MD, FCCP; Alexander H. Flannery, PharmD, BCPS; Steven Q. Simpson, MD, FCCP
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

aDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky, Lexington, Kentucky

bCollege of Pharmacy, University of Kentucky HealthCare, Lexington, Kentucky

cDivision of Pulmonary and Critical Care, University of Kansas, Kansas City, KS

CORRESPONDENCE TO: Angel O. Coz Yataco, MD, FCCP, University of Kentucky, KY Clinic, 740 S Limestone L-543, Lexington, KY 40536


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(6):1368-1370. doi:10.1016/j.chest.2016.03.050
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Hypoalbuminemia is common in patients with severe sepsis and septic shock and is associated with poor outcomes. The use of albumin for resuscitation in this population remains controversial. Despite theoretical benefits to the use of albumin, multiple clinical trials and systematic reviews have failed to demonstrate an outcome benefit. We believe that the use of albumin in the resuscitation of patients with severe sepsis and septic shock is not warranted, given the lack of evidence of outcome benefits and its high cost. We present a few important questions.

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