0
Editorial |

To Sleep, Perhaps to Dream: Sedatives and the Uncertainties Surrounding Therapeutic Choices in Critical Care

Yoanna Skrobik, MD, FCCP
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

CORRESPONDENCE TO: Yoanna Skrobik, MD, FCCP, McGill University Health Centre, Medicine Desk D05.5133, 1001 Blvd Décarie, Montreal, QC H4A 3J1, Canada


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(6):1355-1356. doi:10.1016/j.chest.2016.03.033
Text Size: A A A
Published online

Extract

Intensivists ubiquitously administer sedatives to palliate their patients’ discomfort. However, sedative-associated unresponsiveness confers significant risk and worsens outcomes., Sedative-associated morbid consequences are more likely to occur, given critically ill patients’ unique pharmacokinetics. Protocols mandating sedative titration benefit patients, but the persistence of oversedation,, despite these protocols, suggest that drug–drug interaction and metabolite accumulation may contribute to this iatrogenic complication., Some class-specific pharmacologic characteristics explain the association described between sedative exposure and untoward effects. Overall, the incidence, severity, and cost of sedation-associated problems appear to be rising.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543