Dr Courtright raises some excellent and valid points regarding the debate, and clearly this is an important aspect of improving medical practice. In essence, there are two “camps” of clinical research, those of academia and industry, each with their own perspective and aims. The topic of underrepresented or minority populations in studies has been examined with respect to oncology, multiple sclerosis (MS), stroke, and other conditions. However, before we believe that we have totally failed these populations, it is important to consider the actual incidence of various minorities in the United States in 2014. Almost 80% of US citizens were white; 12.8%, “black”; 4.4%, Asian; and < 1% were American Indian/Alaskan. It is important to remember these data when discussing this sensitive topic. Three specific conditions have been reviewed with respect to minority balance: MS, stroke, and cancer.