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Recent Advances in Chest Medicine |

Management of Myositis-Related Interstitial Lung Disease

Julie Morisset, MD; Cheilonda Johnson, MD; Eric Rich, MD; Harold R. Collard, MD, FCCP; Joyce S. Lee, MD
Author and Funding Information

aDepartment of Medicine, University of California San Francisco, San Francisco, CA

bDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD

cDépartement de Médecine, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada

dDepartment of Medicine, University of Colorado Denver, Aurora, CO

CORRESPONDENCE TO: Joyce S. Lee, MD, 12700 E 19th Ave, C-272, Aurora, CO 80045


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(5):1118-1128. doi:10.1016/j.chest.2016.04.007
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Interstitial lung disease (ILD) is a frequent pulmonary manifestation and an important cause of morbidity and mortality in patients with idiopathic inflammatory myopathy. Myositis-related ILD presents a therapeutic challenge for clinicians, as there are no available guidelines to help with management decisions. This review covers the existing evidence on the pharmacologic and nonpharmacologic management of myositis-related ILD, highlighting the lack of randomized controlled data to guide treatment. Given the absence of existing guidelines to inform treatment decisions, we provide a comprehensive summary, including dosing, side effects, and suggested monitoring of the commonly used immunosuppressive agents and a proposed treatment algorithm based on the existing literature.

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