Tobacco Cessation and Prevention: Smoking and Health |

Immediate Effects of e-Cigarette Smoking in Healthy and Mild Asthmatic Young Smokers FREE TO VIEW

Andreas Lappas, MD; Anna Tzortzi, MD; Efstathia Konstantinidi, MD; Chara Tzavara, PhD; Sofia Gennimata, MD; Nikolaos Koulouris, MD PhD; Panagiotis Behrakis, MD PhD
Author and Funding Information

Biomedical Research Foundation, Academy of Athens, Athens, Greece

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A590. doi:10.1016/j.chest.2016.02.616
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SESSION TITLE: Smoking and Health

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 05:15 PM - 06:15 PM

PURPOSE: E-cigarette smoking (ECS) is increasingly promoted as a safer alternative to cigarette smoking. Our study aimed to investigate the immediate effects of ECS on pulmonary function in healthy and mild asthmatic young smokers.

METHODS: 54 young mild cigarette and experienced e-cigarette smokers (aged 18-31) were enrolled. 27 were healthy and 27 had mild controlled asthma. All subjects smoked the e-cigarette with the cartridge attached at an initial session and served as control group using the device without the cartridge at a different session. We used the same settings (voltage=3.7V, resistance=1.6Ω, 10 puffs of 4sec duration each with 30sec interval between two consecutive puffs), and liquid (nicotine concentration=12mg/ml) for standardization. Impulse oscillometry multi-frequency respiratory system impedance(Z), resistance(R), reactance(X), and exhaled nitric oxide(FENO) were measured before, immediately after, 15 and 30 minutes after ECS or control session. General linear models were used and statistical significance was set at p<0.05.

RESULTS: The interaction effect of time with smoking (ECS vs. control) was significant (p<0.01) for Z5Hz, R5Hz, R10Hz, R20Hz, R5Hz-R20Hz, X10Hz, X20Hz, fres (resonant frequency) and AX (reactance area) at both healthy and asthmatics, expressing the increase of peripheral and central resistance and the reduction of FENO. A significant interaction of asthma with time was found for Z5Hz, R5Hz and R10Hz (p≤0.022), indicating their higher increase in asthmatics compared to healthy smokers. All parameters returned to baseline (pre-smoking) values after 30 minutes in both subpopulations.

CONCLUSIONS: ECS causes acute pulmonary function impairment, lasting for less than 30 minutes after smoking.

CLINICAL IMPLICATIONS: ECS is not safe. As it happens with cigarette smoking, ECS has more pronounced deleterious effects in asthmatics. Further investigation focused on long-term effects of ECS is recommended.

DISCLOSURE: The following authors have nothing to disclose: Andreas Lappas, Anna Tzortzi, Efstathia Konstantinidi, Chara Tzavara, Panagiotis Behrakis, Nikolaos Koulouris

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