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Sleep Disorders: Sleep Disorders III |

Muscularization of Pulmonary Artery and RhoA/ROCK levels in Rats Exposed to Intermittent Hypoxia

Caili Li; Jing Feng
Author and Funding Information

Tianjin Medical University General Hospital, Tianjin, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A587. doi:10.1016/j.chest.2016.02.612
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Intermittent hypoxia (IH), as the most important pathophysiologic characteristic of obstructive sleep apnea (OSA) and a recognized risk factor for cardiovascular disorders, may lead to proliferation of smooth muscle cells (SMCs) and then pulmonary arterial remodeling through the RhoA/ROCK signaling pathway. In this preliminary study, an IH animal model was developed, and the muscularization of small pulmonary arteries and RhoA/ROCK levels in these rats exposed to IH were studied.

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