SESSION TITLE: Sleep Disorders III
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Intermittent hypoxia (IH), as the most important pathophysiologic characteristic of obstructive sleep apnea (OSA) and a recognized risk factor for cardiovascular disorders, may lead to proliferation of smooth muscle cells (SMCs) and then pulmonary arterial remodeling through the RhoA/ROCK signaling pathway. In this preliminary study, an IH animal model was developed, and the muscularization of small pulmonary arteries and RhoA/ROCK levels in these rats exposed to IH were studied.