Sleep Disorders: Sleep Disorders III |

Alteration of Fas/FasL and Bcl-2 Levels in the Serum of Patients With Obstructive Sleep Apnea-Hypopnea Syndrome FREE TO VIEW

Haiyan Zhao, PhD; Ning Zhou, PhD; Jie Cao; Baoyuan Chen
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Tianjin Medical University General Hospital, Tianjin, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A586. doi:10.1016/j.chest.2016.02.611
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) can lead to multi-system and multi-organ damages, which are associated with cell apoptosis. This study aimed to explore the balance of apoptosis and anti-apoptosis in OSAHS patients.

METHODS: Thirty OSAHS patients were selected from July 2010 to July 2011 in Tianjin Medical University General Hospital Respiratory Sleep Center (Tianjin, China). Nocturnal polysomnography (PSG) was performed in each patient, diagnosis and severity was assessed based on the apnea-hypopnea index (AHI). The control group was composed of 30 subjects. OSAHS in the control group was excluded by medical history record and PSG. The level of serum Fas, FasL and Bcl-2 was measured by ELISA.

RESULTS: Our results showed that the level of Fas and FasL in OSAHS patients (109.27±20.15 pg/ml, 1092.92±414.31 pg/ml, respectively) was significantly higher than that in the healthy controls (92.98±16.46 pg/ml, 638.10±253.11 pg/ml, respectively) (P<0.01). In contrast, Bcl-2 level in OSAHS patients (135.82±49.80 pg/ml) was significantly lower than that in the healthy controls (204.21±66.15 pg/ml) (P<0.001). Furthermore, the level of Fas, FasL and Bcl-2 was correlated with the level of sleep breathing-related parameters (AHI, LSpO2 and MSpO2) (P<0.01).

CONCLUSIONS: These results indicated that hypoxia/re-oxygenation can activate apoptotic pathway by promoting pro-apoptotic factors and inhibiting anti-apoptosis factors, leading to excessive cell apoptosis and occurrence of OSAHS symptoms.

CLINICAL IMPLICATIONS: These data may provide new insight into the clinical treatment.

DISCLOSURE: The following authors have nothing to disclose: Haiyan Zhao, Ning Zhou, Jie Cao, Baoyuan Chen

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