SESSION TITLE: Sleep Disorders III
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea (OSA), has been reported to play a key role in the development of obstructive sleep apnea-associated cardiovascular diseases including cardiac hypertrophy. RhoA/ROCK pathway could also induce myocardial remodeling, but the exact mechanisms are not fully elucidated. The current study’s purpose is to investigate the influence of hydroxyfasudil, a selective ROCK inhibitor, on CIH-induced left ventricular remodeling in rats and its possible mechanisms.