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Sleep Disorders: Sleep Disorders III |

Inhibition of Rho-Kinase Attenuates Left Ventricular Remodeling in Chronic Intermittent Hypoxia-Induced Rats by Suppressing Myocardial Inflammation and Apoptosis

Zhihua Wang, MA
Author and Funding Information

Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A585. doi:10.1016/j.chest.2016.02.610
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea (OSA), has been reported to play a key role in the development of obstructive sleep apnea-associated cardiovascular diseases including cardiac hypertrophy. RhoA/ROCK pathway could also induce myocardial remodeling, but the exact mechanisms are not fully elucidated. The current study’s purpose is to investigate the influence of hydroxyfasudil, a selective ROCK inhibitor, on CIH-induced left ventricular remodeling in rats and its possible mechanisms.

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