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Sleep Disorders: Sleep Disorders III |

Intermittent Hypoxia Aggravated Bleomycin-Induced Pulmonary Fibrosis in a Mouse Model of Sleep Apnea

Lian Li, PhD; Fangyuan Ren, BA; Jie Cao, MD; Baoyuan Chen, MD
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Tianjin Medical University General Hospital, Tianjin, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A584. doi:10.1016/j.chest.2016.02.609
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea (OSA) has recently been associated with cardiovascular/ cerebrovascular disease, metabolic disorders, cognitive dysfunction, as well as cancer. However, the association between OSA and pulmonary fibrosis has not been reported. The aim of this work was to study the association between intermittent hypoxia (IH) and pulmonary fibrosis, the effects of IH on pulmonary fibrosis and the interventional role of tempol in mice and cell cultures.

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