Sleep Disorders: Sleep Disorders III |

The Drifting Balance of Toll-Like Receptors and Soluble Toll-Like Receptors in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome FREE TO VIEW

Junjun Huang, MD; Sicong Si; Jing Ma; Guangfa Wang
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Peking University First Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A583. doi:10.1016/j.chest.2016.02.608
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To provide new insight into the expression of TLRs/sTLRs from OSAHS

METHODS: Subjects form the pations, who were suspected OSAHS, were recruited into the cohort study. Expressions of sTLR2 and sTLR4 in plasma were measured by ELISA. While, surface expressions of TLR2 and TLR4 on circulating monocytes and neutrophils were measured by flow cytometry.

RESULTS: ①Subjects (n=58) had divided into simple snoring group (n=10), mild OSAHS group (n=9), moderate OSAHS group (n=4), and severe OSAHS group (n=35), according to polysomnography. ②In OSAHS group and severe OSAHS group, the levels of sTLR2 in plasma were down-regulated. Before sleep VS. after sleep (ng/ml) were 1.041 (0.609,1.997) ng/ml VS. 0.610 (0.580, 0.970) ng/ml, P=0.003; 1.419±1.225 ng/ml VS. 0.620 (0.580, 1.350) ng/ml, P=0.015, respectively. ③In OSAHS group and severe OSAHS group, the surface expressions of TLR2 on neutrophils were up-regulated. Before sleep VS. after sleep (%) were 27.43±14.32 VS 36.10±17.43, P=0.000; 29.83±13.27 VS 39.49±16.75, P=0.001, respectively. ④Linear regression analysis revealed AHI was associated with the levels of sTLR2 in severe OSAHS group before sleep (r=−0.383, P=0.023). The positive correlation was shown between AHI and D-value of sTLR2 through the sleep in severe OSAHS group, with significant statistic (r=0.349, P=0.040).

CONCLUSIONS: In OSAHS subjects, especially in severe OSAHS ones, sTLR2 maybe a negative cycling marker in the inflammatory process of OSAHS for the reduction of sTLR2 after sleep, the negative correlation between AHI and levels of sTLR2 before sleep, and the positive correlation between AHI and D-value of sTLR2 through the sleep.

CLINICAL IMPLICATIONS: In severe OSAHS subjects, the increase of TLR2 on neutrophils while the decrease of sTLR2 in plasma suggested the drifting balance of TLRs/sTLRs may be affected by one night sleep.

DISCLOSURE: The following authors have nothing to disclose: Junjun Huang, Sicong Si, Jing Ma, Guangfa Wang

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