RESULTS:1. In CG the bone cell morphology was normal and the trabecular structure was complete. The bone cells in IH group for four weeks were mild edema, inflammatory cells mild infiltration, trabecular bone quantity reduced; while for six weeks, they were severe significantly. In HI group they were milder than IH group at the same time point. 2. Compared with CG, in IH group TRAP and CB1R was higher, and with the duration of hypoxia it became more remarkable. Compared with IH group, TRAP in the HI group was lower at the same time point. The difference was statistically significant (p < 0.05). 3. Pearson correlation analysis showed that there was a positive correlation between the CB1R and the TRAP activity.