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Sleep Disorders: Sleep Disorders III |

Intermittent Hypoxia Reduces Microglia Proliferation and Induces DNA Damage In Vitro

Song Liu, MD; Zhonghua Wang; Bo Xu; Kui Chen; Lianping Ren, MS; Jinyuan Sun
Author and Funding Information

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A577. doi:10.1016/j.chest.2016.02.602
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SESSION TITLE: Sleep Disorders III

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea (OSA) is a common sleep disorder characterized by recurrent episodes of complete or partial collapse of the upper airway, resulting in nocturnal intermittent hypoxia (IH). This disease has many potential consequences including neurocognitive and behavioral deficits. IH, caused by OSA, could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. The effect of IH on the growth and biological functions of microglia cells was explored.

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