Sleep Disorders: Sleep Disorders II |

Liver Enzymes and Lipid Profile in Han Chinese Subjects With Obstructive Sleep Apnea FREE TO VIEW

Chenjuan Gu, PhD; Qing Yun Li, PhD; Min Li, MD; Jun Zhou, MD; Juan Du, MD; Huahua Yi
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Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medcine, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A574. doi:10.1016/j.chest.2016.02.599
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SESSION TITLE: Sleep Disorders II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To explore the association of obstructive sleep apnea (OSA) with liver enzymes and lipid profile in Han Chinese subjects.

METHODS: A total of 172 Han Chinese subjects, 133 men and 39 women, aged from 18 to 69 years with an average body mass index (BMI) of (33.51±5.90) kg/m2 were enrolled and divided into three groups based on full-night polysomnography (PSG): severe OSA group (AHI>30 events/h), mild to moderate OSA group (5<AHI≤30 events/h) and control group (AHI<5 events/h). Liver enzymes and lipid profile were measured after an overnight fast. Measurements were compared among groups by one-way analysis of variance (ANOVA). Stepwise multiple linear regressions were conducted to determine the independent linear correlation of liver enzymes and lipid profile with PSG parameters.

RESULTS: Serum γ-glutamyltransferase (γ-GT) and triglyceride (TG) levels in OSA groups were higher than those in control group (γ-GT: 25.00, 36.00 and 39.00 U/L; TG: 1.57, 2.09 and 1.96mmol/L respectively in control, mild to moderate and severe OSA group, P<0.05). Alanineaminotransferase (ALT), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) levels were similar among three groups. In stepwise multiple linear regressions, γ-GT was positively correlated with oxygen desaturation index (ODI), male gender and glycosylated hemoglobin A1 (HbA1c) (β=0.185,−0.341 and 0.338 respectively, P<0.05). TG was positively correlated with male gender, concomitant hypertension and HbA1c (β=−0.191, 0.205 and 0.210 respectively, P<0.05).

CONCLUSIONS: Serum γ-GT and TG levels were higher in OSA groups than in control group. γ-GT had independent positive correlation with ODI, while TG had no independent association with PSG parameters.

CLINICAL IMPLICATIONS: To determine the association of OSA with liver injury and impaired lipid metabolism.

DISCLOSURE: The following authors have nothing to disclose: Chenjuan Gu, Qing Yun Li, Min Li, Jun Zhou, Juan Du, Huahua Yi

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