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Sleep Disorders: Sleep Disorders II |

A Correlative Study of OSAHS and Hypercapnia FREE TO VIEW

Xian Wen Sun; Qing Yun Li; Hai Yang Shi
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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A572. doi:10.1016/j.chest.2016.02.597
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SESSION TITLE: Sleep Disorders II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a chronic sleep respiratory disease with nocturnal hypoxemia and continuous hypercapnia. The key determinants of hypercapnia in OSAHS are unclear.

METHODS: 70 OSAHS patients were measured by overnight polysomnography (PSG), Epworth Sleepiness Scale (ESS), carbon dioxide monitoring in end-tidal (PETCO2Q) and prolonged expiration (more than 5 seconds) (PETCO2P) at bedtime and in the morning. These patients were divided equally into 4 groups according to PSG results: control group with an apnea-hypopnea index (AHI) <5 (n=17), mild group (5 ≤ AHI <15) (n=17), moderate group (15 ≤ AHI <30) (n=18) and severe group (AHI ≥30) (n=18).

RESULTS: There were no significant differences between PETCO2Q and PETCO2P at bedtime and in the morning respectively. But PETCO2P levels were higher than PETCO2Q. The difference of PETCO2P and PETCO2Q (△PETCO2) had no relationships with AHI, lowest oxygen saturation (LSaO2), sex, age and smoke. But △PETCO2 had positive relationships with the percent of SaO2<90% in one night sleep (SIT90), Body Mass Index (BMI), Neck circumference, waist circumference and ESS (r=0.625, r=0.429, r=0.424, r=0.335, r=0.387, p<0.05).

CONCLUSIONS: Hypercapnia occurs in a large part of patients with OSAHS. Nocturnal hypoxemia and obesity are all contributed to the development of daytime CO2 retention in OSAHS.

CLINICAL IMPLICATIONS: Nocturnal hypoxemia and obesity are all contributed to the development of daytime CO2 retention in OSAHS.

DISCLOSURE: The following authors have nothing to disclose: Xian Wen Sun, Qing Yun Li, Hai Yang Shi

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