RESULTS: The study recruited subjects from May 2009 to October 2009, 77 patients with OSA with CPAP therapy. There is 67 cases of men (87.0%); Women in 10 cases (13.0%). The average age is 61.61±7.22 years old. AHI is 28.89±15.86 times/h, ODI is 25.90 ±13.51 times/h. At the end of follow-up, the observation time is 3.2±1.2 years. Except 1 case died, 1 case lost to follow-up, 11 cases halfway down, a total of 64 patients who included in on long-term family CPAP treatment of patients with complete follow-up, CPAP treatment time is 4.81±1.66 hours. Machine more than 4 hours per night for adherence to good standards, adherence to good is 43 cases, accounting for 67.2%; Poor adherence of 21 cases, accounting for 32.8%. Relatively poor compliance and good compliance of two groups of patients with symptoms, signs, AHI, average lowest SaO2, SaO2, differences were no significant difference (P > 0.05), and compare the two groups of pressure titration results show that good compliance group 5.89±1.28 h per night, poor compliance group 5.03±1.37 h per night, good adherence to treatment time is higher than the poor group (P < 0.05). Analysis of CPAP therapy trend of long-term adherence, the result shows: the good compliance group in the treatment of the first three months increased, then outer-plane changes. Analysis results showed that patients with midway stop of 3 cases of incomplete pressure titration, 8 cases of the shortest time for 3 months, the longest 3 years, the average time of 22.88±12.82 months. Main reasons for give up treatment are insomnia, unadapt and local irritation symptoms.