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Sleep Disorders: Sleep Disorders I |

Applicability of Visceral Adiposity Index in Predicting Metabolic Syndrome in Adults With Obstructive Sleep Apnea FREE TO VIEW

Qi-Chang Lin, PhD; Qi Jiachao; Lin XIn
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Fujian Provincial Sleep-Disordered Breathing Clinic Center, Laboratory of Respiratory Disease of the Fujian Medical University; Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A567. doi:10.1016/j.chest.2016.02.592
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea (OSA) is severely affected by visceral adiposity (VA) that correlates to another disorder—metabolic syndrome (MetS). However, little is known concerning the relation of VAI, a novel and simple surrogate indicator of VA, with OSA and MetS. The objective of the study was to analyze the association of VAI with both disorders and applicability to identify OSA patients at risk of MetS

METHODS: We consecutively enrolled individuals undergoing polysomnography and biochemical tests and analyzed differences in all subjects grouped by oxygen desaturation index (ODI). Receiver operating characteristic (ROC) curve was conducted to obtain a cut-off value of VAI for predicting incident MetS. Logistic regression was performed to identify the risk of MetS in OSA patients according to the cut-off point.

RESULTS: A total of 289 individuals were enrolled in the study. 219 subjects were found ODI>5/h (78 patients in mild OSA group, 66 in moderate and 74 in severe). A significant increasing trend among groups were observed in the indices of metabolic score and VAI (P=0.001, p=0.018, respectively). Additionally, a significant negative association with high-density lipoprotein-cholesterol (HDL-C) was observed (P=0.002). Both metabolic score and VAI were significantly correlated with waist circumference, body mass index, diastolic blood pressure, triglycerides, HDL-C, apnea-hypopnea index, ODI, mean nocturnal oxygen saturation and the percentage of sleep duration with SpO2<90% (all P<0.05). ROC curve showed a VAI of 1.739 had a sensitivity of 85.0% and a specificity of 70.3% in determining the occurrence of MetS in OSA patients. OSA patients with VAI≥1.739 tended to have significantly greater risk in incident MetS (odds ratio=13.957, p=0.000).

CONCLUSIONS: The present study demonstrated the impact of noctunal oxyhemoglobin desaturations on the metabolism. VAI, associated with metabolic score and OSA and obtained in everyday practice, may offer a powerful tool to identify patients with OSA at risk of MetS.

CLINICAL IMPLICATIONS: VA correlates to OSA and MetS which predispose patients to cardiovascular diseases. Chinese have a greater amount of VA than Europeans. VAI is a relaible surrogate indicator of VA. To our knowledge, though the applicability of VAI in early determining metabolic risk has been described, little information is available regarding the relation between VAI and OSA. We suggested VAI was closely associated with both OSA and MetS, and explored its role in predicting MetS in OSA, improving the management of the complication of OSA.

DISCLOSURE: The following authors have nothing to disclose: Qi-Chang Lin, Qi JIachao, Lin XIn

No Product/Research Disclosure Information


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