Sleep Disorders: Sleep Disorders I |

Ten-Year Cardiovascular Morbidity Risk Prediction in a Cohort of Newly Diagnosed Patients With Obstructive Sleep Apnea FREE TO VIEW

Evangelia Nena, PhD; Drosos Tsavlis, PhD; Panagiota Karailidou, MD; Maria Strempela, MD; Maria Xanthoudaki, MD; Athanasios Voulgaris, MD; Stylianos Steiropoulos, MD; Theodoros Constantinidis, PhD; Marios Froudarakis, PhD; Paschalis Steiropoulos, PhD
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Demokritus University of Thrace, Alexandroupolis, Greece

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A563. doi:10.1016/j.chest.2016.02.588
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive Sleep Apnea (OSA) is associated with increased cardiovascular morbidity and mortality. The aim of this study was to assess whether the 10-year risk for cardiovascular disease in newly diagnosed patients with OSA is increased.

METHODS: Totally 347 (77.5% males and 22.5% females) consecutive newly diagnosed OSA patients were included in the study. The mean age of the population was 51.3 years (±11.2). The diagnosis of OSA was set with Polysomnography. The Systematic Coronary Risk Evaluation (SCORE) and the Framingham Risk Score (FRS) were applied in order to estimate the 10-year risk for cardiovascular disease.

RESULTS: 1) Mild OSA with Apnea Hypopnea Index (AHI): 5.1 - 15/hour was diagnosed in 98 patients (28.2%), 2) Moderate OSA with AHI: 15.1 - 30/hour was diagnosed in 60 patients (17.3%) and 3) Severe OSA with AHI >30/hour was diagnosed in 189 patients (54.5%). The mean SCORE value was 1.8% (±1.6) and the mean FRS value was 9.6% (±7.2). Increased OSA severity was associated with increased SCORE (p=0.001) and FRS values (p<0.001). More specifically, a statistically significant correlation was observed between AHI and SCORE values (r=0.112, p=0.037) and between AHI and FRS values (r=0.160, p=0.003). Furthermore, a negative correlation was found between FRS values and sleep efficiency (r=−0.163, p=0.037).

CONCLUSIONS: The 10-year risk for cardiovascular morbidity in a cohort of OSA patients increases along with the severity of OSA.

CLINICAL IMPLICATIONS: Sleep physicians should bear in mind the result of this study in order to seek for the risk factors for cardiovascular disease and try to eliminate them. Therefore, future cardiovascular events could be prevented from OSA patients.

DISCLOSURE: The following authors have nothing to disclose: Evangelia Nena, Drosos Tsavlis, Panagiota Karailidou, Maria Strempela, Maria Xanthoudaki, Athanasios Voulgaris, Stylianos Steiropoulos, Theodoros Constantinidis, Marios Froudarakis, Paschalis Steiropoulos

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