Sleep Disorders: Sleep Disorders I |

Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis FREE TO VIEW

Li-Da Chen, MD; Qi-Chang Lin, MD; Jian-Nan Liu, MD
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Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A562. doi:10.1016/j.chest.2016.02.587
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Obstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; However, previous studies assessing the effect of CPAP on adiponectin in patients with OSA yielded conflicting results. The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels.

METHODS: Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before February 2015. Information on characteristics of subjects, study design and pre- and post-CPAP treatment of serum adiponectin was extracted for analysis. Standardized mean difference (SMD) was used to analyze the summary estimates for CPAP therapy.

RESULTS: Eleven studies involving 240 patients were included in this meta-analysis, including ten observational studies and one randomized controlled study. The meta-analysis showed that there was no change of adiponectin levels before and after CPAP treatment in OSA patients (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z=0.37, p=0.710), even subdivided by age, baseline body mass index (BMI), severity of OSA, CPAP therapy duration, sample size and racial differences.

CONCLUSIONS: This meta-analysis suggested that CPAP therapy has no impact on adiponectin in OSA patients, without significant changes in body weight. Further large-scale, well-designed long-term interventional investigations are needed to clarify this issue.

CLINICAL IMPLICATIONS: Our meta-analysis did not demonstrate a significant effect of CPAP treatment in improving the adiponectin levels in OSA patients, without significant changes in BMI.

DISCLOSURE: The following authors have nothing to disclose: Li-Da Chen, Qi-Chang Lin, Jian-Nan Liu

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