Sleep Disorders: Sleep Disorders I |

Correlation Between Severity of Coronary Artery Lesions and Middle-Term Prognosis With Obstructive Sleep Apnea-Hypopnea Syndrome in Acute Coronary Syndrome Patients FREE TO VIEW

Yiliang Su, MD; Huiping Li, MD
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Shanghai Pulmonary Hospital, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A560. doi:10.1016/j.chest.2016.02.585
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the correlation between severity of coronary artery lesions and middle-term prognosis with obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with acute coronary syndrome (ACS).

METHODS: A total of 123 patients with ACS were classified into four groups according to results of coronary angiography (CAG) and polysomnography (PSG): ACS group (group Ⅰ, n=31), ACS complicated with mild OSAHS (group Ⅱ, n=31), ACS complicated with moderate OSAHS (group Ⅲ, n=31), ACS complicated with severe OSAHS (group Ⅳ, n=30). Patients’ information including age, sex, body mass index, history of hypertension, diabetes mellitus, family, smoke, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), results of CAG and PSG were collected. Coronary artery lesions’ were compared by Gensini score. The relationship between Gensini score and apnea hypopnea index (AHI) and minimum SaO2 during sleep at night were analyzed. The patients were followed up for six months, and the amounts of cardiovascular composite endpoint in four groups were compared.

RESULTS: Compared with group Ⅰ, AHI of group Ⅱ, Ⅲ and Ⅳ were much higher (P<0.01), SaO2 of group Ⅱ, Ⅲ and Ⅳ were much lower (P<0.01). Compared with group Ⅱ, AHI of group Ⅲ and Ⅳ were much higher (P<0.01), SaO2 of group Ⅲ and Ⅳ were much lower (P<0.01). There was no significant difference in AHI and SaO2 between group Ⅲ and Ⅳ (P>0.05). There was no significant difference in Gensini score between group Ⅱ and Ⅰ (P>0.05). Compared with group Ⅱ and Ⅰ, Gensini score of group Ⅲ and Ⅳ were much higher (P<0.01). Gensini score of group Ⅳ was higher than group Ⅲ (P<0.05). Gensini score was positively correlated with AHI (r=0.506, P<0.01) and negatively with SaO2 (r=−0.730, P<0.01). Incidence of cardiovascular composite endpoint events during six months in four groups were 19.35%, 22.58%, 32.26%, 43.33% respectively. The group Ⅳ’s cardiovascular composite endpoint events was higher than group Ⅰ (P<0.05). TC, TG, LDL-C and classification of OSAHS are independent predictors for cardiovascular composite endpoint events.

CONCLUSIONS: Moderate and severe OSAHS is related to the severity of coronary artery lesions in patients with ACS.

CLINICAL IMPLICATIONS: Complicated OSAHS in patients with ACS may increase the incidence rate of cardiovascular composite endpoint events, especially severe OSAHS. OSAHS is an independent predictor for cardiovascular composite endpoint events in patients with ACS.

DISCLOSURE: The following authors have nothing to disclose: Yiliang Su, Huiping Li

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