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Sleep Disorders: Sleep Disorders I |

Obstructive Sleep Apnea is Associtated With Fatty Liver Index, the Index of Hepatic Steatosis: A Crossover Study FREE TO VIEW

Xiao Chen; Qi-Chang Lin
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Fuzhou Affiliated Hospital of Fujian Medical University, Fuzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A559. doi:10.1016/j.chest.2016.02.584
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SESSION TITLE: Sleep Disorders I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The relationship between obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) is gaining increased attention. The aim of present study was to examine the effect of OSA on hepatic steatosis defined by elevated fatty liver index (FLI).

METHODS: A total of 145 consecutive patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for biological profile measurements, and demographic data were collected. FLI was calculated using body mass index, waist circumference, triglycerides, and gamma glutamyltransferase for each patient.

RESULTS: Subjects with FLI≥60 had significantly lower lowest O2 saturation (73 vs. 83%, p<0.001), lower mean nocturnal oxygen saturation (93 vs. 95%, p<0.001), higher apnea-hypopnea index (40 vs. 18, p<0.001), higher oxygen desaturation index (39 vs. 11, p<0.001) and higher percentage of sleep time spent with SpO2<90% (5 vs. 1%, p<0.001) compared with those with FLI<60. In multivariate analysis, the presence of OSA was independently associated with elevated FLI after adjusting for confounding factors (odds ratio, 4.213; 95% confidence interval, 1.380 to 12.859, p=0.012).

CONCLUSIONS: Our results suggest that the occurrence of OSA was independently associated with hepatic steatosis defined by elevated FLI. Further studies are required to determine the impact of OSA treatment on the outcomes of patients with NAFLD.

CLINICAL IMPLICATIONS: The fatty liver index showed good predictive value for the detection of fatty liver and was validated in a large cohort of subjects with and without suspected liver disease. Our reseach demonstrated that there were relatively severe PSG parameters of sleep apnea in high FLI group, the presence of OSA was independently associtaed with hepatic steatosis defined by elevated FLI.

DISCLOSURE: The following authors have nothing to disclose: Xiao Chen, Qi-Chang Lin

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