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Sleep Disorders: Sleep Disorders: Effects of Intermittent Hypoxia |

Chronic Intermittent Hypoxia Impairs Glucose Homeostasis and Activates Endoplasmic Reticulum Stress Signaling/c-Jun N-Terminal Kinase Pathway in C57BL6/J Mice

Juan Du, MD; Chenjuan Gu; Min Li; Qing Yun Li
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Shanghai Ruijin Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A558. doi:10.1016/j.chest.2016.02.583
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SESSION TITLE: Sleep Disorders: Effects of Intermittent Hypoxia

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM

PURPOSE: The aim of this study was to explore the effect of chronic intermittent hypoxia (CIH) on glucose metabolism, as well as Akt (protein kinase B kinase, one important kinase in insulin signaling) and markers of endoplasmic reticulum (ER) stress/ JNK in insulin target organs.

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