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Sleep Disorders: Sleep Disorders: Effects of Intermittent Hypoxia |

Relevant Mechanism of Intermittent Hypoxia-Induced Melanoma Lung Metastases in a Murine Model of Sleep Apnea

Lian Li, PhD; Fangyuan Ren; Jie Cao; Baoyuan Chen, MD
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Tianjin Medical University General Hospital, Tianjin, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A556. doi:10.1016/j.chest.2016.02.581
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SESSION TITLE: Sleep Disorders: Effects of Intermittent Hypoxia

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM

PURPOSE: Obstructive sleep apnea (OSA) has been recently associated with tumor incidence and cancer-related mortality. Intermittent hypoxia (IH) mimicking OSA contributes to tumor growth and metastasis in a mouse model. The aim of this study was to investigate the hypothesis that IH exposure enhances melanoma metastasis to the lung via increases of HIF-1α and its target proteins associated with metastasis, as well as changes of epithelial-mesenchymal (EMT) / mesenchymal-epithelial transition (MET)-related proteins and oxidative stress-responsive and inflammatory transcription factors.

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