SESSION TITLE: Sleep Disorders: Effects of Intermittent Hypoxia
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM
PURPOSE: Obstructive sleep apnea (OSA) has been recently associated with tumor incidence and cancer-related mortality. Intermittent hypoxia (IH) mimicking OSA contributes to tumor growth and metastasis in a mouse model. The aim of this study was to investigate the hypothesis that IH exposure enhances melanoma metastasis to the lung via increases of HIF-1α and its target proteins associated with metastasis, as well as changes of epithelial-mesenchymal (EMT) / mesenchymal-epithelial transition (MET)-related proteins and oxidative stress-responsive and inflammatory transcription factors.