RESULTS: The following findings were deteced a) Serum Ad level was the lowest in CIH group but the highest in NC group with CIH+ad group in between (all P<0.05) b) Twitch tension, time to peak tension, half relaxation time and tetanic tension were significantly lower in CIH group than those in NC group (P<0.01). Those contractile properties were improved in CIH+Ad group (P<0.05).c) Tetanic fatigue indexes of three groups were decreased more rapidly in the first 20 seconds than those in the following 100 seconds. Tetanic fatigue indexes in NC and CIH+Ad groups were significantly higher than that in CIH group. d) Compared with control group, in CIH group, mitochondrial number was significantly reduced and structure was remarkably impaired, In addition, there was a significant decrease in expression of pathway protein of LKB1-AMPK-PGC1-α. The above changes in CIH group was significantly improved in CIH+Ad group.