Sleep Disorders: Sleep Disorders: Effects of Intermittent Hypoxia |

Effects and Mechanisms of Chronic Intermittent Hypoxia on Genioglossal Contractile Properties and Interventive Role of Adiponectin FREE TO VIEW

Xilong Zhang, PhD; Hanpeng Huang; Xiaofeng Zhang
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The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A555. doi:10.1016/j.chest.2016.02.580
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SESSION TITLE: Sleep Disorders: Effects of Intermittent Hypoxia

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM

PURPOSE: To investigate the effects of chronic intermittent hypoxia (CIH) on genioglossal contractile properties, the intervention role of adiponectin (Ad) and associated mechanisms.

METHODS: Thirty-nine healthy Wistar rats were randomly divided into 3 groups, normal control (NC) group, CIH group and CIH+Ad group with 13 rats in each. Rats in NC group were kept breathing normal air, while rats in both CIH and CIH+Ad groups were exposed to same CIH environment (8h/day for successive 35 days). Rats in CIH+Ad group were given intravenous Ad supplement. After CIH exposure, the levels of serum Ad and genioglossus contractile properties, number and structure of mitochondia as well as fiber type of genioglossus were compared among different groups.

RESULTS: The following findings were deteced a) Serum Ad level was the lowest in CIH group but the highest in NC group with CIH+ad group in between (all P<0.05) b) Twitch tension, time to peak tension, half relaxation time and tetanic tension were significantly lower in CIH group than those in NC group (P<0.01). Those contractile properties were improved in CIH+Ad group (P<0.05).c) Tetanic fatigue indexes of three groups were decreased more rapidly in the first 20 seconds than those in the following 100 seconds. Tetanic fatigue indexes in NC and CIH+Ad groups were significantly higher than that in CIH group. d) Compared with control group, in CIH group, mitochondrial number was significantly reduced and structure was remarkably impaired, In addition, there was a significant decrease in expression of pathway protein of LKB1-AMPK-PGC1-α. The above changes in CIH group was significantly improved in CIH+Ad group.

CONCLUSIONS: CIH could lead to hypoadiponectinemia, impaired genioglossus contractile properties in rats. Such changes might be associated with the CIH induced mitochondrial impairment and muscular fiber type changes. Supplement of adiponectin could improved CIH induced pathological changes.

CLINICAL IMPLICATIONS: Choronic intermittent hypoxia (CIH) and upper airway dilating muscle dysfunction were considered as the key pathological changes in obstructive sleep apnea. Genioglossus was also the key dilating muscle in upper airway. The correlation between CIH and genioglosal impairment need to be elucidated. By investogating the coorelation betewwn CIH and genioglossus as well as the possible protective role of adiponectin (Ad), The current study was carried out to explore the pathogenesis of obstructive sleep apnea and possible novel therapy.

DISCLOSURE: The following authors have nothing to disclose: Xilong Zhang, Hanpeng Huang, Xiaofeng Zhang

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