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Sleep Disorders: Sleep Disorders: Effects of Intermittent Hypoxia |

Effects and Mechanisms of Chronic Intermittent Hypoxia on Genioglossal Contractile Properties and Interventive Role of Adiponectin

Xilong Zhang, PhD; Hanpeng Huang; Xiaofeng Zhang
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The First Affiliated Hospital of Nanjing Medical University, Nanjing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A555. doi:10.1016/j.chest.2016.02.580
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SESSION TITLE: Sleep Disorders: Effects of Intermittent Hypoxia

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM

PURPOSE: To investigate the effects of chronic intermittent hypoxia (CIH) on genioglossal contractile properties, the intervention role of adiponectin (Ad) and associated mechanisms.

METHODS: Thirty-nine healthy Wistar rats were randomly divided into 3 groups, normal control (NC) group, CIH group and CIH+Ad group with 13 rats in each. Rats in NC group were kept breathing normal air, while rats in both CIH and CIH+Ad groups were exposed to same CIH environment (8h/day for successive 35 days). Rats in CIH+Ad group were given intravenous Ad supplement. After CIH exposure, the levels of serum Ad and genioglossus contractile properties, number and structure of mitochondia as well as fiber type of genioglossus were compared among different groups.

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