Sleep Disorders: Obstructive Sleep Apnea |

Obstructive Sleep Apnea Is Risk Factor for Osteoarthritis FREE TO VIEW

Asiye Kanbay; Erkan Ceylan, MD; Aylin Pihtili, MD; Selcan Tulu, MD
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Istanbul Medeniyet University School Medicine Department of Pulmonary Medicine, Istanbul, Turkey

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A553. doi:10.1016/j.chest.2016.02.578
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SESSION TITLE: Obstructive Sleep Apnea

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 01:00 PM - 02:00 PM

PURPOSE: Recent studies showed that that osteoarthritis (OA) is associated with cardiovascular disease and inflammation due to this OA defined as “metabolic disorder”. Obstructive sleep apnea syndrome (OSAS) is closely associated with cardiovascular and metabolic disorders. Intermittent hypoxia, systemic inflammation and sympathetic activation are the main causes of cardiometabolic derangements in OSAS. With this background in mind, we aimed to evaluate the role of OSAS in the development of OA severity and to investigate whether there is an association between severity of OSAS and OA severity.

METHODS: This was a cross-sectional study in which patients who had undergone a polysomnographic study for diagnosis of OSAS were recruited. Included patients were grouped according to apnea-hypopnea index (AHI) as mild (AHI between 5 and 14.9) and moderate (AHI between 15 and 29,9) severe OSAS (AHI ≥ 30). Patients with AHI < 5 served as control group. Kellgren-Lawrence scoring system was used for evaluation of OA severity and graded as Grade 0, 1, 2, 3 and 4. Body-mass index (BMI) was calculated and high-sensitive C-reactive protein was measured.

RESULTS: One hundred twenty-three patients were enrolled to the study. The mean age was 51.7±11.9 years and 70% (70/123) of the patients were male. BMI measurements were similar for OA groups. Meanwhile, we found a strong correlation between severity of OSAS and severity of OA. In Grade 4 (severe) OA group (33 patients), all patients had severe OSAS and this association was independent from BMI. In Grade 0 and Grade 1 (mild) OA group none of the patients had severe OSAS (p<0.05). There was also a positive correlation between severity of OSAS, OA and hs-CRP.

CONCLUSIONS: OSAS is a novel independent risk factor for development and severity OA of which is independent from BMI. Further studies should be evaluated the effect of OSAS treatment on OA.

CLINICAL IMPLICATIONS: OSAS might be a new etiological factor for OA

DISCLOSURE: The following authors have nothing to disclose: Asiye Kanbay, Erkan Ceylan, Aylin Pihtili, Selcan Tulu

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