RESULTS: A total of 227 patients with asthma were enrolled, with 131 CPA and 96 NCPA. The prevalence of symptoms was as following: dyspnea (80.6%), wheeze (86.4%), cough (92.5%), chest tightness (56.4%). The major troublesome symptoms were dyspnea (43.6%), wheeze (41.9%), cough (60.4%), chest distress (7.8%). The initial symptoms ranging from highest to lowest proportions were cough (57%), dyspnea (17.3%), wheeze (14.3%), chest distress (3.7%). Compared with NCPA, patients with CPA had higher VAS score (p<0.001) and Neu% (p=0.03) in sputum. However, There were no significant differences in Eos% (P=0.46), age, gender, duration and combined diseases (AR, ST, GER and bronchiectasis) between CPA and NCPA. FEV1%pred, FEV1/FVC% and MMEF%pred were similar between two groups. There was a higher trend of cough hypersensitivity in CPA patients as compared with NCPA (64% vs. 36.4%, p=0.059).