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Signs and Symptoms of Chest Diseases: Cough |

Comparison of Clinical Characteristics and Responsiveness to Bronchodilator Between Cough Variant Asthma and Eosinophilic Bronchitis

Fang Yi, MD; Lina Han; Baojuan Liu; Wei Luo, BA; Qiaoli Chen; KeFang Lai, PhD
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Guangzhou Institute of Respiratory Diseases, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A550. doi:10.1016/j.chest.2016.02.574
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SESSION TITLE: Cough

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 08:30 AM - 09:30 AM

PURPOSE: To study the clinical characteristics, airway inflammation and the responsiveness to bronchodilator in patients with cough variant asthma (CVA) and eosinophilic bronchitis (EB).

METHODS: According to diagnostic algorithm of Chinese Cough Guideline, patients with EB or CVA were enrolled from February 2013 to February 2015. Clinical characteristics were recorded. Sputum induction, spirometry and cough challenge test were performed in all patients. Cough sensitivity was quantified by the value of capsaicin concentration induced 5 or more cough and expressed as logC5. All subjects received 10mg Bambuterol Hydrochloride tablets (treatment group) or placebo (control group) in a randomized manner. After 3 days treatment period, the remission rate were compared and the clinical characteristics, airway inflammation, cough sensitivity and lung function were subsequently analyzed.

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