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Signs and Symptoms of Chest Diseases: Cough |

Efficacy of Oral Specific Neuromodulators on Human Refractory Chronic Cough: A Systematic Review and Meta-analysis

Weili Wei; Yangzi ZhangTong; Mei He; Hanjing Lv; Zhongmin Qiu
Author and Funding Information

Tongji Hospital, Tongji University School of Medicine, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A548. doi:10.1016/j.chest.2016.02.572
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Extract

SESSION TITLE: Cough

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 08:30 AM - 09:30 AM

PURPOSE: To evaluated the efficacy and safety of oral specific neuromodulators on refractory chronic cough.

METHODS: We assessed clinical and preclinical RCTs studies of the neuromodulating agents, baclofen, amitriptyline, gabapentin, deanxit and pregbalin, for the treatment of human cough with no restriction to language. Data were extracted from PubMed, EMBASE, LILACS, CBM, CNKI, VIP, WanFang and Cochrane Controlled Trials Register (CENTRAL) databases. Literature was searched by the two authors with a priori criteria for study selection. The outcome data were number of possible cases whose cough threshold to inhaled capsaicin C5 changed or those cough symptom improved, measured by cough or LCQ score, after treatment.

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