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Signs and Symptoms of Chest Diseases: Cough |

A Randomized Clinical Trial of Levodropropizine Effect on Respiratory Centre Output in Patients With Intractable Chronic Cough: Preliminary Results

Claudia Mannini, MD; Federico Lavorini, MD; Federico Saibene, MD; Giovanni Fontana, MD; Luigi Lanata, MD
Author and Funding Information

Dompè, Milano, Italy


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A546. doi:10.1016/j.chest.2016.02.570
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SESSION TITLE: Cough

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Cough is produced by the same neuronal pool implicated in respiratory rhythm generation and antitussive drugs acting at the central level, such as the opioids, may depress ventilation. Levodropropizine is an effective, well tolerated, non-opioid, peripherally-acting antitussive drug; the drug exerts its peripheral action by inhibiting the release of neuropeptides from airway sensory nerves, particularly C-fibers. Little evidence exists demonstrating that Levodropropizine is devoid of any significant action at the central level. The aim of the study was to investigate the effects of Levodropropizine on the respiratory response to a standard CO2 re-breathing testing in both normal subjects and in patients with intractable chronic cough of any origin. We also wished to compare the effects of Levodropropizine with those of codeine, a widely used opioid central acting antitussive agent.

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