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Signs and Symptoms of Chest Diseases: Cough |

Validation of Chinese Version of Hull Airway Reflux Questionnaire and Its Application in the Management of Chronic Cough FREE TO VIEW

Yun Huang, MD; Xianghuai Xu, MD; Yu Li, MD; Qiang Chen, MD; Hanjing Lv, MD; Zhongmin Qiu, MD
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Tongji Hospital, Tongji University School of Medicine, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A542. doi:10.1016/j.chest.2016.02.566
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SESSION TITLE: Cough

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The purpose of the study is to validate the Chinese version of HARQ, and explore its application in the management of chronic cough.

METHODS: A standard Chinese version of HARQ was developed by an established translation procedure. Its repeatability and score changes in the different causes of chronic cough were evaluated in 78 patients with chronic cough and 15 healthy volunteers respectively. Receiver operating characteristic analysis was employed to evaluate the diagnostic value of HARQ.

RESULTS: The repeatability of the Chinese version of HARQ was validated at a 2-week interval with the intraclass correlation coefficients of 0.926. The patients with chronic cough had higher HARQ score than healthy volunteers (20.7±10.4 vs 4.6±2.1, t=3.904, P=0.000). Among all the patients with variable causes of chronic cough, the patients with gastroesophageal reflux-induced cough presented with the highest HARQ score. When used for the prediction of cough due to gastroesophageal reflux, the optimal cut-off point of HARQ was defined at 23.5 according to the highest Youden index of 0.577, with a sensitivity of 85.7%, specificity of 72.0%, positive predictive value of 58.3% and negative predictive value of 92.6%. A sub-analysis only for cough dut to acid reflux showed the predictive accuracy of HARQ was further improved, corresponding to sensitivity of 87.5%, specificity of 83.9%, positive predictive value of 57.1% and negative predictive value of 96.9%. A meaningful cut-off point of HARQ could not be determined for the prediction of cough due to non-acid reflux.

CONCLUSIONS: Chinese version of HARQ is a validated tool for management of chronic cough and may be used to predict the cough due to gastroesophageal reflux, especially due to acid reflux.

CLINICAL IMPLICATIONS: Hull Airway Reflux Questionnaire (HARQ) is a valid measure for chronic cough hypersensitivity syndrome.

DISCLOSURE: The following authors have nothing to disclose: Yun Huang, Xianghuai Xu, YU Li, Qiang Chen, Hanjing Lv, Zhongmin Qiu

No Product/Research Disclosure Information


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