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Signs and Symptoms of Chest Diseases: Cough |

Induction of Airway Remodeling by Repeated Citric Acid Exposure in Guinea-Pig Cough Model

Shilei Cui, MD; Isao Ito, PhD; Hitoshi Nakaji, PhD; Akio Niimi, PhD; Huili Zhu, MD
Author and Funding Information

Department of Respiratory Medicine, Kyoto University, Kyoto, Japan


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A539. doi:10.1016/j.chest.2016.02.563
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SESSION TITLE: Cough

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Airway remodeling is a prominent feature in chronic cough. We previously studied 22days-model of citric acid induced cough model of guinea pigs. We found repeated cough itself induced increase of airway smooth muscle area in the peripheral airways, associated with increased number of cough. Pathological changes of airways produced by mechanical stress with cough itself in more prolonged cough models are still unknown. The objective of this research is to study pathological changes in the airways in prolonged cough models of guinea pigs.

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