Signs and Symptoms of Chest Diseases: Cough |

Combination of NSAID and Antitussives in Treatment of URTI Related Cough: An Observational Study FREE TO VIEW

Alessandro Zanasi, MD; Luigi Lanata, MD; Federico Saibene, MD; Francesco De Blasio, MD
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Dompé Farmaceutici, Milano, Italy

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A538. doi:10.1016/j.chest.2016.02.562
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Cough is the commonest symptom of clinical importance and the most frequent reason for new consultations with a doctor. The annual prevalence of cough in the general population is reported as 10-33%. The most common causes of acute cough are infections of the upper respiratory tract (URTIs). There are evidence that NSAIDs are used to improve cough concerning common cold, and the last ACCP cough guideline recommend the use of naproxen in cough caused by cold. Moreover cough often requires treatment with antitussives as it could have a great impact on quality of adults’ life.

METHODS: This is an observational, prospective study evaluating 149 patients affected by URTI treated with a combination of antitussives and NSAIDs. A Verbal Category Descriptive score (VCD) was used to evaluate cough, considering two periods, 7 and 10 days respectively, from the beginning of the treatment. On VCD score was also conducted an analysis on persistence of cough (Kaplan Meier) taking into account absence of coughing (VCD score=0) or its presence (VCD score>0).

RESULTS: Drugs more frequently used in combination in this study are levodropropizine and ketoprofen lysine salt (KLS). We observed a statistically significant difference in terms of days required for a complete resolution of cough between the group receiving KLS in combination with levodropropizine (a peripheral antitussive) and the group treated with KLS in combination with central antitussives, in favor of the first one. In the group treated with KLS and central antitussives the median persistence of cough was 11 days, while in the group treated with the combination KLS and levodropropizine the median was 7 days.

CONCLUSIONS: The present study suggests that the association of either central and peripheral antitussives with different NSAIDs is efficacious in the reduction of coughing days. Moreover the combination levodropropizine and KLS shows better result compared with other combinations.

CLINICAL IMPLICATIONS: The association of antitussive and NSAIDs could be an effective therapy for URTI related cough, and the better result are achieved by the combination ketoprofen lysine salt and levodropropizine.

DISCLOSURE: Luigi Lanata: Employee: Medical department Federico Saibene: Employee: Medical department The following authors have nothing to disclose: Alessandro Zanasi, Francesco De Blasio

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