Signs and Symptoms of Chest Diseases: Cough |

Antitussive, Antiinflammatory and Antioxidant Activity of Polysaccharides From Asarum Heterotropoides in a Guinea Pig Model for Chronic Cough Induced by Cigarette Smoke Exposure FREE TO VIEW

XiaoDong Liu, PhD; KeFang Lai, PhD
Author and Funding Information

Guangzhou Institute of Respiratory Disease, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A537. doi:10.1016/j.chest.2016.02.561
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE:AsarumHeterotropoides (Xi Xin) is a traditional Chinese medicine commonly used for the treatment of chronic cough. Volatile components are known to be potent cough modulators. However, the reports of polysaccharides isolated from A.Heterotropoides on cough are unknown. This study aimed to evaluate the antitussive, anti-inflammatory and antioxidant effects of Asarum polysaccharide (PSA) in a guinea pig model for chronic cough.

METHODS: This study established a guinea pig model of cough hypersensitivity induced by 14 days of cigarette smoke (CS) exposure, to evaluate the antitussive, antioxidant, and anti-inflammatory effects of PSA.

RESULTS: Physic-chemical analysis revealed that the PSA contained 60.3% of total carbohydrate content, which was isolated from the A. Heterotropoides, mainly including glucose (74.05%), mannose (18.37%), arabinose (4.68%), galactose (1.54%). CS-enhanced cough in guinea pigs model was significantly inhibited after 14 days use of PSA at dosages of 200, 400, 800 mg/kg. 54.0%, 62.6% and 70.9% inhibition were found respectively at different dosages of PSA while 81.1% inhibition was found at a single dose of codeine phosphate (30 mg/kg) in compared with CS-exposure guinea pigs. Meanwhile, the CS-induced increase for the number of total cells and percentage of neutrophils in BALF, as well as the levels of TNF-α and IL-8 in lung tissue homogenate, were markedly decreased after treatment with PSA (200, 400, 800 mg/kg) for 14 days. The inflammation in lung tissue improved after treatment. The activities of SOD and GSH-Px in lung tissue were elevated, while the level of MDA was markedly decreased after oral administration of PSA.

CONCLUSIONS: PSA from A. Heterotropoides have significant antitussive activity in a guinea pig model for chronic cough induced by CS-exposure, which might be related with anti-inflammatory and antioxidant activity.

CLINICAL IMPLICATIONS: PSA provided a novel remedy of drug development for chronic cough.

DISCLOSURE: XiaoDong Liu: University grant monies: The First Affiliated Hospital, Guangzhou Medical University KeFang Lai: University grant monies: The First Affiliated Hospital, Guangzhou Medical University





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