0
Pulmonary Vascular Disease: Pulmonary Vascular Disease: VTE |

Predictive Value of the High-Sensitivity Troponin I Assay in Patients With Acute Pulmonary Embolism FREE TO VIEW

Xin Xi, MD
Author and Funding Information

Beijing Anzhen Hospital, Capital Medical University, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A525. doi:10.1016/j.chest.2016.02.547
Text Size: A A A
Published online

SESSION TITLE: Pulmonary Vascular Disease: VTE

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To evaluate the predictive value of the high-sensitivity cardiac troponin I (hs-cTnI) assay in patients with acute pulmonary embolism (APE).

METHODS: In a retrospective cohort study, 272 consecutive patients with APE were reviewed and the 30-days death and in-hospital adverse events were evaluated. The patients were classified according to hs-cTnI value into high hs-cTnI group and low hs-cTnI group. The simple Pulmonary Embolism Severity Index (sPESI) was used for clinical risk determination. The adverse events was defined as intravenous thrombolytic therapy, noninvasive ventilator support to maintain oxygen saturation > 90% and suffered with severe complications. The correlations of hs-cTnI with sPESI score, 30-days adverse events and mortality were analyzed. The Kaplan-Meyer curves and the log-rank test were used to compare time-to-event survival. Stepwise multivariate logistic regression analysis models were used to determine the incremental prognostic value of PESI score and hs-cTnI.

RESULTS: The incidence of 30-day death, renal failure, bleeding, shock and thrombolytic therapy were higher in increased hs-cTnI group than in normal hs-cTnI group (P values were 0.009, <0.001, 0.018 and 0.003, respectively). Patients with normal hs-cTnI had greater free adverse events survival (P <0.001). Hs-cTnI provided incremental predictive value for in-hospital adverse events, beyond the PESI (P <0.001).

CONCLUSIONS: Highly sensitive cTnI has excellent negative predictive value for APE prognostic.

CLINICAL IMPLICATIONS: Our study shows the excellent negative predictive value of highly sensitive cTnI for APE prognostic.

DISCLOSURE: The following authors have nothing to disclose: Xin Xi

No Product/Research Disclosure Information


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543