Pulmonary Vascular Disease: Pulmonary Vascular Disease: VTE |

Predictive Value of the High-Sensitivity Troponin I Assay in Patients With Acute Pulmonary Embolism FREE TO VIEW

Xin Xi, MD
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Beijing Anzhen Hospital, Capital Medical University, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A525. doi:10.1016/j.chest.2016.02.547
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SESSION TITLE: Pulmonary Vascular Disease: VTE

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To evaluate the predictive value of the high-sensitivity cardiac troponin I (hs-cTnI) assay in patients with acute pulmonary embolism (APE).

METHODS: In a retrospective cohort study, 272 consecutive patients with APE were reviewed and the 30-days death and in-hospital adverse events were evaluated. The patients were classified according to hs-cTnI value into high hs-cTnI group and low hs-cTnI group. The simple Pulmonary Embolism Severity Index (sPESI) was used for clinical risk determination. The adverse events was defined as intravenous thrombolytic therapy, noninvasive ventilator support to maintain oxygen saturation > 90% and suffered with severe complications. The correlations of hs-cTnI with sPESI score, 30-days adverse events and mortality were analyzed. The Kaplan-Meyer curves and the log-rank test were used to compare time-to-event survival. Stepwise multivariate logistic regression analysis models were used to determine the incremental prognostic value of PESI score and hs-cTnI.

RESULTS: The incidence of 30-day death, renal failure, bleeding, shock and thrombolytic therapy were higher in increased hs-cTnI group than in normal hs-cTnI group (P values were 0.009, <0.001, 0.018 and 0.003, respectively). Patients with normal hs-cTnI had greater free adverse events survival (P <0.001). Hs-cTnI provided incremental predictive value for in-hospital adverse events, beyond the PESI (P <0.001).

CONCLUSIONS: Highly sensitive cTnI has excellent negative predictive value for APE prognostic.

CLINICAL IMPLICATIONS: Our study shows the excellent negative predictive value of highly sensitive cTnI for APE prognostic.

DISCLOSURE: The following authors have nothing to disclose: Xin Xi

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