Pulmonary Vascular Disease: Pulmonary Vascular Disease: VTE |

Serum CA125 Level in Patients With Acute Pulmonary Thromboembolism FREE TO VIEW

Li Xu, MS; Kejing Ying, MD; Ruifeng Zhang, PhD
Author and Funding Information

Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Chin

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A517. doi:10.1016/j.chest.2016.02.539
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SESSION TITLE: Pulmonary Vascular Disease: VTE

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Carbohydrate antigen 125 (CA125) have been found elevated in many diseases other than ovary carcinoma. This study is to investigate the relationship between CA125 level and severity stratification of acute pulmonary thromboembolism.

METHODS: A total of 77 patients suffering from acute pulmonary thromboembolism were enrolled into our study. These patients were divided into 3 groups: Group I (low risk group, n=25), Group II (intermediate-low risk group, n=28) and Group III (intermediate-high risk and high risk groups, n=24) according to the classification standard of 2014 ESC Guidelines. Control group was consisted of 38 age-sex matched healthy persons. CA125 level were measured in all subjects. Data were analyzed with Kruskal-Wallis tests, chi-squared tests or one-way ANOVA

RESULTS: The mean level of CA125 in group III (44.6±43.0 U/ml) was significantly higher than that in group II (19.0±11. P<0.05), group I (11.0±4.6. p<0.001) and control group (11.0±3.8. P<0.001). It was also significantly higher in group II than that of group I and control group (P<0.05). BNP and PASP were positively correlated with CA125 (respectively, r=0.574, p<0.001; r=0.390, p=0.006), LVEF were negatively correlated with CA125 (r= (0.102, p=0.009).

CONCLUSIONS: CA125 level in patients with acute pulmonary thromboembolism might due to the severity of the disease. The serum level of CA125 was positively correlated with the value of BNP and PASP, but negatively correlated with LVEF

CLINICAL IMPLICATIONS: The measurement of CA125 is a noninvasive and convenient assay. A persistent increase or decrease in the value of CA125 may respectively indicate an invalid or valid response to the therapy in patients with CHF. Thus, we may assume the possibility of the serum assay of CA125 as a prognostic value in patients suffering of acute PTE. The level of CA125 may probably become an useful index to therapy guiding. BNP is widely applied in the evaluation and severity stratification of cardiac dysfunction, and it was also a predictor of long-term prognosis in patients with acute PTE. On the basis of our and others studies, the level of CA125 was positively correlated with the level of BNP. We assume CA125 may not only act as a promising biomarker for the severity prediction and prognostic evaluation of acute PTE, but contribute to therapeutic schedule adjustment in subsequent follow-up.

DISCLOSURE: The following authors have nothing to disclose: Li Xu, Kejing Ying, Ruifeng Zhang

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