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Pulmonary Vascular Disease: Pulmonary Vascular Disease: PAH |

Long-Term Mechanical Ventilation as Adjunctive Therapy for Children With Severe Pulmonary Hypertension

Paul Sammut, MBBCh
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University of Nebraska Medical Center, Omaha, NE


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A515. doi:10.1016/j.chest.2016.02.537
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Extract

SESSION TITLE: Pulmonary Vascular Disease: PAH

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The mortality rate of infants with severe chronic lung disease and pulmonary hypertension (PH) remains very high at around 70%, despite the availability of multiple vasodilator agents which have greatly improved the survival of children with pulmonary hypertension in general. The effects of hypercarbia on pulmonary artery pressure (PAP) have been shown to be variable, but most clinicians believe it has a significant pulmonary vasoconstricting effect and a negative effect on the vasodilating capability of other agents. Mechanical ventilation has the capability of improving the level of hypercarbia in these patients and, therefore, the potential to improve the severity of pulmonary hypertension. Very few clinical studies have been done on this topic and almost no reports can be found in the pediatric literature.

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