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Pulmonary Vascular Disease: Pulmonary Vascular Disease: PAH |

The C-Terminal Tail of Aquaporin 1 Is Required for Hypoxia-Induced Migration and Proliferation of Pulmonary Arterial Smooth Muscle Cells

Ning Lai; Xin Yun; Jian Wang; Larissa Shimoda
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Guangzhou Institute of Respiratory Diseases, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A514. doi:10.1016/j.chest.2016.02.536
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SESSION TITLE: Pulmonary Vascular Disease: PAH

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Both pulmonary arterial smooth muscle cell (PASMC) proliferation and migration are important contributors to the vascular remodeling that occurs during the development of pulmonary hypertension. We previously demonstrated that aquaporin 1 (AQP1), a member of the water channel family of proteins was expressed in PASMCs and necessary for hypoxia-induced migration; however, the mechanism by which AQP1 controls this response is unclear. The C-terminal tail of AQP1 contains putative calcium (EF-hand) and protein binding sites. Thus, we wanted to explore whether the C-terminal tail or EF-hand motif of AQP1 was required for migration and proliferation.

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