SESSION TITLE: Pulmonary Vascular Disease: PAH
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Both pulmonary arterial smooth muscle cell (PASMC) proliferation and migration are important contributors to the vascular remodeling that occurs during the development of pulmonary hypertension. We previously demonstrated that aquaporin 1 (AQP1), a member of the water channel family of proteins was expressed in PASMCs and necessary for hypoxia-induced migration; however, the mechanism by which AQP1 controls this response is unclear. The C-terminal tail of AQP1 contains putative calcium (EF-hand) and protein binding sites. Thus, we wanted to explore whether the C-terminal tail or EF-hand motif of AQP1 was required for migration and proliferation.