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Pulmonary Vascular Disease: Pulmonary Vascular Disease: PAH |

Effects of Chronic Exposure to Cigarette Smoke on Canonical Transient Receptor Potential Expression in Rat Pulmonary Arterial Smooth Muscle

Ruimin Hu; Yuqin Chen; Dejun Sun; Jian Wang
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Inner Mongolia People’s Hospital, Huhhot, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A510. doi:10.1016/j.chest.2016.02.532
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SESSION TITLE: Pulmonary Vascular Disease: PAH

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To clarify the possible mechanism of chronic cigarette smoke (CS)-induced pulmonary hypertension and furthermore provide effective targets for prevention and treatment.

METHODS: The effects of chronic CS on rat pulmonary arterial smooth muscle in vivo and nicotine treatment on rat PASMCs in vitro were investigated. A fluorescence microscope was used to measure the basal intracellular calcium concentration ([Ca2+]i) and store operated calcium entry (SOCE) in rat PASMC; The expression of transient receptor potential 1 (TRPC1) and transient receptor potential 6 (TRPC6) at both mRNA and protein levels in isolated distal PA was examinated using Western blot and real-time PCR.

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