Pulmonary Vascular Disease: Pulmonary Vascular Disease: PAH |

Accuracy of Doppler Echocardiography in the Assessment of Pulmonary Arterial Hypertension In Patients With Congenital Heart Disease FREE TO VIEW

Bo Wang; Haixia Zhou; Jing Yang; Binmiao Liang; Yulin Feng, MD
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Department of Respiratory Medicine, West China Hospital, Chengdu, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A509. doi:10.1016/j.chest.2016.02.531
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SESSION TITLE: Pulmonary Vascular Disease: PAH

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with congenital heart disease (CHD). Therefore, earlier diagnosis of PAH would be of great benefit for the estimation of the CHD, the grasp of the indications for surgery and prognosis.

METHODS: We assessed the diagnostic accuracy of Doppler echocardiography (D-ECHO) in detecting PAH in patients with CHD and the value of estimation about ventricular morphology and function of PAH-CHD patients. One hundred and twenty three CHD patients evaluated for suspected PAH were prospectively recruited. D-ECHO was performed and estimated right ventricular systolic pressure (RVSP) was measured to screen for PAH. Subsequently, pulmonary hemodynamic parameters were measured by right heart catheterization (RHC) for definitive diagnosis of PAH. The results of the two methods were compared to assess the screening effect of D-ECHO.

RESULTS: RHC identified 66/123 (54%) patients with PAH. The noninvasive cut-point was: estimated right ventricular systolic pressure (RVSP) > 36.5 mm Hg by D-ECHO. D-ECHO classified 107 subjects correctly (59/66 with and 48/57 without PH; sensitivity 89.4%, specificity 84.2%). The area under receiver-operating characteristic curve (AUC) was 0.96 for D-ECHO. A positive significant correlation (r=0.853, P<0.01) was found between RVSP measured by D-ECHO and systolic pulmonary arterial pressure (sPAP) measured by RHC. Similar positive significant correlation (r=0.790, P<0.01) was also found between RVSP measured by D-ECHO and mean pulmonary arterial pressure (mPAP) measured by RHC. In addition, D-ECHO showed higher RVSP, left ventricular internal diameter (LV), right atrial diameter (RA), right ventricular internal diameter (RV), left ventricular end-diastolic diameter (EDD), left ventricular diastolic end-diastolic volume (EDV) and mitral velocity A wave (AMV) values in the PAH-CHD group than in the CHD group (P<0.05).

CONCLUSIONS: Our data revealed a strong correlation between Doppler echocardiographic assessment and direct hemodynamic measurement of pulmonary artery pressures in patients with congenital heart disease.

CLINICAL IMPLICATIONS: D-ECHO is not only an important noninvasive diagnostic technique for PAH-CHD patients, but also a tool which can indicate the ventricular remodeling and diastolic dysfunction induced by PAH to some extent.

DISCLOSURE: The following authors have nothing to disclose: Bo Wang, Haixia Zhou, Jing Yang, Binmiao Liang, Yulin Feng

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