RESULTS: Between March 2012 and April 2015 three patients with severe PH and concomitant hematological malignancy were implanted at our center. According to our standard operating procedures all patients were uptitrated with subcutaneous treprostinil. Eligibility for anesthesia and pump implantation were independently assessed by the PH specialist, the anesthesiologist and the surgeon. All implantations at our center are performed by a dedicated surgical team. No perioperative complications were observed. In patient 3 a postoperative bleeding episode was managed during hospital stay. No other complications, especially no infections were observed. Patient 1 deceased 12 months after pump implantation due to the underlying malignancy. Currently a fourth patient, a 65 year old female with a diagnosis of post polycythemia vera myelofibrosis is on the waiting list for implantation as thrombocytopenia - a known side effect of ruxolitinib - is for now a contraindication for surgery.