Pulmonary Vascular Disease: Pulmonary Vascular Disease |

Severe Respiratory Failure Due to Interferon Beta-Related Pulmonary Hypertension FREE TO VIEW

Antonello Nicolini, MD
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Respiratory Diseases Unit, Sestri Levante, Italy

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A499. doi:10.1016/j.chest.2016.02.521
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SESSION TITLE: Pulmonary Vascular Disease

SESSION TYPE: Case Report Poster

PRESENTED ON: Sunday, April 17, 2016 at 11:45 AM - 12:45 PM

INTRODUCTION: Pulmonary arterial hypertension (PAH) is an uncommon but devastating disease. There is increasing evidence of a correlation between interferon (IFN) use and PAH. Very few cases of PAH in patients treated with IFN are reported in literature.

CASE PRESENTATION: We report a case of a 47 year old woman with previous diagnosis of multiple sclerosis (MS) treated with IFN β-1a for six years presenting severe respiratory failure (paO2/FiO2 228) due to pulmonary hypertension. The suspension of the drug along with the treatment of PAH improved the clinical picture allowing cessation of oxygen administration.

DISCUSSION: Interferon beta side effects are increasing; the number of associated secondary pathologies are also on the rise [5]. Evidence of a correlation between IFN use and PAH is increasing In the literature only a case series and sporadic cases of PAH correlated with these drugs (no more than twenty) have been described. Recent experimental studies have suggested that IFN could promote endothelial dysfunction increasing the release of endothelin-1 by human vascular cells.

CONCLUSIONS: With the increased use of IFNs we should expect more cases in the future. Clinicians should be aware of this possible treatable cause of PAH.

Reference #1: 1. Savale L, Sattler C, Gunther S, Montani D, Chaumains MC, Perrin S et al. Pulmonary arterial hypertension in patients treated with interferon. ERJ 2014;44:1627-1634

Reference #2: Gibbons E, Promislow S, Davies RA, Chandy G, Stewart DJ, Vladimir CD et al. Reversible pulmonary arterial hypertension associated with interferon-beta treatment for multiple sclerosis Can Resp J 2015; Jun 17, pli 16820 [Epub ahead of print ]

DISCLOSURE: The following authors have nothing to disclose: Antonello Nicolini

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