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Pulmonary Vascular Disease: Pulmonary Arterial Hypertension |

Cardiovascular Parameters of Chest CT Scan in Estimating Pulmonary Arterial Pressure in Patients With Pulmonary Hypertension FREE TO VIEW

Mengxi Li, MD; Shouyang Wang, MD; Weiquan Lin, MD; Jinhui Li, MD; Qingsi Zeng, CCP; Jian Wang, PhD
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Guangzhou Institute of Respiratory Disease, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A496. doi:10.1016/j.chest.2016.02.518
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SESSION TITLE: Pulmonary Arterial Hypertension

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 01:00 PM - 02:00 PM

PURPOSE: To develop a formula to compute mean pulmonary arterial pressure (MPAP) by chest computerized tomography (CT), and to verify its accuracy and reliability.

METHODS: 85 patients who had taken chest CT and right heart catheterization (RHC) were recruited. The pulmonary arterial systolic pressure (PASP), pulmonary arterial diastolic pressure (PADP) and MPAP of each subject were measured and recorded by right heart catheterization (RHC). The diameters of the ascending aorta (dAA), descending aorta (dDA) and main pulmonary artery (dMPA), Cobb angle, diameters of right ventricle (dRV), diameters of left ventricle (dLV) were measured by means of chest CT scans. Systolic blood pressure (SBP) was measured using electronic sphygmomanometer. A linear regression equation was generated in 56 patients to estimate PAP based on chest CT values, 29 patients were used to test the accuracy of the formula.

RESULTS: The computed equation for analyzing MPAP is: MPAP = 9.011 + 34.195 * dMPA/dAA - 0.319* SBP + 0.402 * Cobb angle. AUC of equation with three variables (dMPA/dAA, SBP and Cobb angle) was 0.923 with 95% CI (0.863-0.982). The mean ± SD of predicted values and RHC values had no statistical difference.

CONCLUSIONS: Ratio of dMAP/dAA, Cobb angle and SBP can be reliably used estimate to MPAP and predict severity of PH.

CLINICAL IMPLICATIONS: We consider this novel method relatively easy to operate, with higher security and efficiency. It has the potential to be widely used in clinical prediction of PAP in PH patients and deserves further evaluation in future larger population-based study.

DISCLOSURE: The following authors have nothing to disclose: Mengxi Li, Shouyang Wang, Weiquan Lin, Jinhui Li, Qingsi Zeng, Jian Wang

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